Protect your dog from flea infestations with Advantage II Large Dog, a monthly topical flea and lice treatment formulated for dogs and puppies weighing 21–55 lbs. The product is approved for dogs 7 weeks of age and older and works against adult fleas, flea larvae, and flea eggs.

Key Features

1. Advantage II for Large Dogs
2. For dogs weighing 21–55 lbs
3. Suitable for dogs and puppies 7 weeks and older
4. Monthly topical treatment
5. Kills adult fleas, flea larvae, and flea eggs
6. Treats and controls chewing lice infestations
7. Starts killing fleas within 12 hours
8. Protection lasts approximately 30 days / 4 weeks
9. Waterproof after 24 hours
10. Fragrance-free formula

Product Specifications

1. Brand: Advantage II
2. Manufacturer: Elanco
3. Product: Advantage II Large Dog
4. Target Animal: Dogs
5. Weight Range: 21–55 lbs
6. Minimum Age: 7 weeks
7. Active Ingredients: Imidacloprid 9.10% + Pyriproxyfen 0.46%
8. Application: Topical / Spot-On
9. Tube Size: 0.085 fl oz / 2.5 mL per tube
10. EPA Registration: 11556-127

Available Pack Sizes

Advantage II Large Dog is available in 4-dose and 6-dose packages, equivalent to approximately 4 or 6 monthly treatments.

If your inventory is the 4-dose package, use:

Advantage II Large Dog 21–55 lbs | 4 Monthly Treatments

If it is the 6-dose package, use:

Advantage II Large Dog 21–55 lbs | 6 Monthly Treatments

How to Use

Apply the contents of one tube directly to the dog’s skin, following the application instructions on the package. Treatment is generally repeated monthly. Use the weight-specific product corresponding to your dog’s current weight.

Important Safety Information

For dogs and puppies only. Do not use the dog formulation on cats. The Large Dog version is specifically intended for dogs weighing 21–55 lbs and at least 7 weeks old.

Do not substitute this product for another weight category. If the dog weighs over 55 lbs, the Extra Large Dog formulation is required. Consult a veterinarian before use on breeding, pregnant, nursing, weak, or debilitated animals.